I will talk about recent work towards a conjecture of Gonek regarding negative shifted moments of the Riemann zeta-function. I will explain how to obtain asymptotic formulas when the shift in the Riemann zeta function is big enough, and how we can obtain non-trivial upper bounds for smaller shifts. I will also discuss some applications to the question of obtaining cancellation of averages of the Mobius function. Joint work with H. Bui.