A major trend in non-commutative harmonic analysis is to investigate function spaces related to Fourier analysis (and representation theory) of non-abelian groups.The Fourier algebra, which is associated with the regular representation of the ambient group, is an important example of such function spaces. These function algebras encode the properties of the group in various ways; for instance the non-existence of derivations on such algebras indicates their lack of analytic properties, which in turn translates into forms of either commutativity or discreteness for the group itself. In this talk, we present explicit constructions of continuous derivations on the Fourier algebras of two important matrix groups, namely the group of ${\mathbb R}$-affine transformations and the Heisenberg group. Using the structure theory of Lie groups, we extend our results to semisimple Lie groups and nilpotent Lie groups.